Backup Server Solution in production environment

Backup Server Solution in production environment

I was looking at setting up a backup server running on a virtualbox with
Windows Server 2008r2 as the host (I have no say here). I was thinking
about using FreeNAS with ZFS, however, I am finding out that some have had
problems with this due to S.M.A.R.T. and windows paging when running
FreeNAS on a virtual Machine.
This Backup Server will be responsible for backing up our whole
infrastructure in increments of a week (already have an on site full
backup solution).
Does Windows have any backup server-client applications that would both be
VM friendly and have the performance to backup TeraBytes of data?
hardware specs are not a problem here.
Thank you in advance!